mSal-Ez: Multiplex ELISA
- Multiplex ELISA-based Salivary assay for early detection
- mSal-Ez: Multiplex ELISA
MSCTR | Cancer Research |Translational Research
mSal-Ez is a non-invasive test developed for screening, early detection, and longitudinal surveillance of oral pre-cancer and cancer.
The assay is based on two MSMF-developed salivary biomarkers (S100A7 and S100P). As a non-invasive medium, saliva enables risk assessment without the discomfort or low compliance associated with biopsy-based approaches and supports repeat testing during follow-up.
Clinical validation across 350+ samples has demonstrated strong diagnostic performance for OPMDs, high-grade dysplasia, and oral cancer. Previous studies conducted showed 87% sensitivity & 92% specificity in distinguishing OSCC/OPMDs from benign oral conditions, and 96% sensitivity & 92% specificity in identifying OPMDs using saliva samples. The assay is currently being evaluated in multi-centric studies and developed for point-of-care deployment.
1) Sivadasan, P., Gupta, M. K., Sathe, G., Sudheendra, H. V., Sunny, S. P., Renu, D., Hari, P. S., Gowda, H., Suresh, A., Kuriakose, M. A., & Sirdeshmukh, R. (2020). Salivary proteins from dysplastic leukoplakia and oral squamous cell carcinoma and their potential for early detection. Journal of Proteomics, 212, 103574.
https://doi.org/10.1016/j.jprot.2019.103574
Molecular Marker Based Oral Cytology For Detection Of Potentially Malignant And Malignant Oral Lesion (No :391264)
