{"id":4016,"date":"2026-04-01T11:37:33","date_gmt":"2026-04-01T11:37:33","guid":{"rendered":"https:\/\/arranstudio.com\/msctr\/?post_type=doctor&#038;p=4016"},"modified":"2026-05-29T08:36:54","modified_gmt":"2026-05-29T08:36:54","slug":"dr-smitha-pk","status":"publish","type":"doctor","link":"https:\/\/arranstudio.com\/msctr\/doctor-post\/dr-smitha-pk\/","title":{"rendered":"Dr. Smitha P.K., Ph.D."},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"4016\" class=\"elementor elementor-4016\" data-elementor-post-type=\"doctor\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9348ab0 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no wpr-column-slider-no wpr-equal-height-no e-con e-parent\" data-id=\"9348ab0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\r\n\r\n\r\n\r\n\r\n\r\n\t\t<div class=\"elementor-element elementor-element-557e5f2 elementor-widget elementor-widget-Limpid_Doctor_Details_V1\" data-id=\"557e5f2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"Limpid_Doctor_Details_V1.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t        <div class=\"container\">\n            <div class=\"row\">\n                <div class=\"col-lg-7\">\n                    <div class=\"man-details\">\n                        <div class=\"image\">\n                                                            <img decoding=\"async\" src=\"https:\/\/arranstudio.com\/msctr\/wp-content\/uploads\/2026\/05\/Dr.-Smitha.jpeg\" alt=\"Dr. Smitha P.K., Ph.D.\">\n                                                    <\/div>\n                        <div class=\"content\">\n                                                            <h3>Dr. Smitha P.K., Ph.D.<\/h3>\n                                                                                        <span>Product Research Group and Gynecologic Oncology division<\/span>\n                                                        \n                            <ul class=\"experience\">\n                                                                                            <\/ul>\n\n                                                        <ul class=\"social-list\">\n                                                                    <li>\n                                        <a href=\"#\" target=\"_blank\" rel=\"nofollow\">\n                                                                                    <\/a>\n                                    <\/li>\n                                                            <\/ul>\n                            \n                        <\/div>\n                    <\/div>\n                    <div class=\"team-introduction\">\n                                                                        <ul>\n                                                            <li>\n                                                                                                        <\/li>\n                                                    <\/ul>\n                                                                            <p><p><b>Dr. Smitha P.K., Ph.D.<\/b><span style=\"font-weight: 400\"> leads the <\/span><b>Product Research Group and Gynecologic Oncology division<\/b><span style=\"font-weight: 400\">, bringing over 18+ years of experience in molecular diagnostics, immune theragnostics, and translational research. She received her doctoral training in molecular biology and immunology from Bharathiar University and has over 12+ years of biotechnology industry experience spanning research, product development, and clinical translation. She is an expert in the development and characterization of monoclonal hybridomas, recombinant antibodies, and therapeutic proteins, and has led the development of several diagnostic platforms. Her contributions are reflected in peer-reviewed publications, filed patents, and ongoing translational innovations.\u00a0<\/span><\/p><p><span style=\"font-weight: 400\">Her current research integrates product development with gynecologic oncology, with a major focus on <\/span><b>ovarian cancer<\/b><span style=\"font-weight: 400\">, where she is developing <\/span><b>patient-derived 3D organoid platforms<\/b><span style=\"font-weight: 400\"> for functional drug testing. These models enable <\/span><b>cell-based assays<\/b><span style=\"font-weight: 400\"> to evaluate chemotherapy response, support personalized treatment strategies, and critically, <\/span><b>investigate the molecular and functional mechanisms underlying drug resistance<\/b><span style=\"font-weight: 400\">. In addition to functional screening, her work focuses on understanding how tumor heterogeneity, microenvironmental factors, and intercellular communication contribute to the emergence and propagation of chemoresistance, enabling the development of more effective therapeutic strategies.<\/span><\/p><p><span style=\"font-weight: 400\">In parallel, she is actively working on the <\/span><b>early detection of cervical cancer<\/b><span style=\"font-weight: 400\">, developing novel diagnostic approaches aimed at improving screening, early intervention, and patient outcomes.<\/span><\/p><\/p>\n                                                \n                                                                                                            <p>&gt; <\/p>\n                                                                        <\/div>\n                <\/div>\n                <div class=\"col-lg-5\">\n                    <div class=\"patients-review\">\n                                                    <h4>What patients are saying<\/h4>\n                                               \n                                <div class=\"spr-review-form-area\">\n            <div id=\"spr-review-form-4016\" class=\"spr-review-form\" data-post-id=\"4016\">\n                \n                                \n                                    <form method=\"post\" action=\"https:\/\/arranstudio.com\/msctr\/wp-admin\/admin-post.php\" class=\"spr-form\">\n                                            <input type=\"hidden\" name=\"action\" value=\"spr_submit_review\" \/>\n                    <input type=\"hidden\" name=\"spr_post_id\" value=\"4016\" \/>\n                    <input type=\"hidden\" name=\"spr_redirect\" value=\"https:\/\/arranstudio.com\/msctr\/doctor-post\/dr-smitha-pk\/\" \/>\n                                            <input type=\"hidden\" name=\"spr_manual_override\" value=\"1\" \/>\n                                                                <input type=\"hidden\" id=\"spr_nonce\" name=\"spr_nonce\" value=\"ec1026422e\" \/><input type=\"hidden\" name=\"_wp_http_referer\" value=\"\/msctr\/wp-json\/wp\/v2\/doctor\/4016\" \/>\n                        <p class=\"spr-field spr-field--rating\">\n                            <label for=\"spr-rating\" class=\"spr-label\">Rating *<\/label>\n                            <select name=\"spr_rating\" id=\"spr-rating\" required>\n                                                                    <option value=\"5\"  selected='selected'>\n                                        5 star(s)                                    <\/option>\n                                                                    <option value=\"4\" >\n                                        4 star(s)                                    <\/option>\n                                                                    <option value=\"3\" >\n                                        3 star(s)                                    <\/option>\n                                                                    <option value=\"2\" >\n                                        2 star(s)                                    <\/option>\n                                                                    <option value=\"1\" >\n                                        1 star(s)                                    <\/option>\n                                                            <\/select>\n                        <\/p>\n\n                        <p class=\"spr-field spr-field--title\">\n                            <label for=\"spr-title\" class=\"spr-label\">Title<\/label>\n                            <input type=\"text\" id=\"spr-title\" name=\"spr_title\" value=\"\" maxlength=\"120\" \/>\n                        <\/p>\n\n                        <p class=\"spr-field spr-field--content\">\n                            <label for=\"spr-content\" class=\"spr-label\">Review *<\/label>\n                            <textarea id=\"spr-content\" name=\"spr_content\" rows=\"6\" required><\/textarea>\n                        <\/p>\n\n                                                    <p class=\"spr-field spr-field--name\">\n                                <label for=\"spr-name\" class=\"spr-label\">Name *<\/label>\n                                <input type=\"text\" id=\"spr-name\" name=\"spr_name\" value=\"\" required \/>\n                            <\/p>\n\n                            <p class=\"spr-field spr-field--email\">\n                                <label for=\"spr-email\" class=\"spr-label\">Email *<\/label>\n                                <input type=\"email\" id=\"spr-email\" name=\"spr_email\" value=\"\" required \/>\n                            <\/p>\n                        \n                        <p class=\"spr-submit\">\n                            <button type=\"submit\" class=\"spr-button\">Submit Review<\/button>\n                        <\/p>\n                    <\/form>\n                            <\/div>\n        <\/div>\n                            <\/div>\n                    <div class=\"team-address-details\">\n                                                    <h4>Address<\/h4>\n                                                <ul class=\"address-list\">\n                                                        <li>\n                                <h6>Address: <\/h6>\n                                <span>Billrothstrasse 78, 1190 Vienna, Austria<\/span>\n                            <\/li>\n                                                                                    <li>\n                                <h6>Email: <\/h6>\n                                <a href=\"mailto:limpid@info.com\">limpid@info.com<\/a>\n                            <\/li>\n                                                                                    <li>\n                                <h6>Phone: <\/h6>\n                                <a href=\"tel:+1(213)555-3890\">+1(213)555-3890<\/a>\n                            <\/li>\n                                                    <\/ul>\n\n                        <div class=\"working-hour\">\n                                                            <h4>Working Hours<\/h4>\n                            \n                                                        <ul>\n                                                                    <li>\n                                        Monday  <span>8AM-7PM<\/span>\n                                    <\/li>\n                                                                    <li>\n                                        Tuesday  <span>8AM-7PM<\/span>\n                                    <\/li>\n                                                                    <li>\n                                        Wednesday  <span>8AM-7PM<\/span>\n                                    <\/li>\n                                                                    <li>\n                                        Thursday  <span>8AM-7PM<\/span>\n                                    <\/li>\n                                                                    <li>\n                                        Saturday  <span>8AM-7PM<\/span>\n                                    <\/li>\n                                                            <\/ul>\n                                                    <\/div>\n                    <\/div>\n                <\/div>\n            <\/div>\n        <\/div>\n        \t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6e4e99c e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no wpr-column-slider-no wpr-equal-height-no e-con e-parent\" data-id=\"6e4e99c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-514e3e0 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no wpr-column-slider-no wpr-equal-height-no e-con e-child\" data-id=\"514e3e0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-74a4972 elementor-widget elementor-widget-heading\" data-id=\"74a4972\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Publications<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b2ae292 elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"b2ae292\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-dot-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 8C119.033 8 8 119.033 8 256s111.033 248 248 248 248-111.033 248-248S392.967 8 256 8zm80 248c0 44.112-35.888 80-80 80s-80-35.888-80-80 35.888-80 80-80 80 35.888 80 80z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Dwivedi N, Mazumder T, Tihara S, Veeraraghavan G, Siva R, Smitha PK, Ranade R, KM A, Dhar SK, Das M. In vitro and In Vivo Evidences Propound Potential of Lipocalin 2 as a Therapeutic Target in Cervical Carcinoma. Journal of Cancer Science and Clinical Therapeutics. 2023;7:233-48.<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-dot-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 8C119.033 8 8 119.033 8 256s111.033 248 248 248 248-111.033 248-248S392.967 8 256 8zm80 248c0 44.112-35.888 80-80 80s-80-35.888-80-80 35.888-80 80-80 80 35.888 80 80z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Nehanjali Dwivedi, Hafsa Bahaar, DN Shashank, Christine Elizabeth Cherry, Charitha Gangadharan, Amritha Suresh, Moni A Kuriakose, Vijay Pillai, Smitha PK, and Manjula Das. Novel cancer associated fibroblasts from diverse locales enhance the tumorigenicity of tongue Tumor Epithelia. Dental Research and Oral Health. 6 (2023): 65-78.<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-dot-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 8C119.033 8 8 119.033 8 256s111.033 248 248 248 248-111.033 248-248S392.967 8 256 8zm80 248c0 44.112-35.888 80-80 80s-80-35.888-80-80 35.888-80 80-80 80 35.888 80 80z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Choudhary BS, Chaudhary N, Shah M, Dwivedi N, P K Smitha, Das M, Dalal SN. Lipocalin 2 inhibits actin glutathionylation to promote invasion and migration. FEBS Lett. 2023 Jan 17. doi: 10.1002\/1873-3468.14572. Epub ahead of print. PMID: 36650979.<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-dot-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 8C119.033 8 8 119.033 8 256s111.033 248 248 248 248-111.033 248-248S392.967 8 256 8zm80 248c0 44.112-35.888 80-80 80s-80-35.888-80-80 35.888-80 80-80 80 35.888 80 80z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Joshi, Anju, Anil Vishnu GK, Smitha P.K, Ashlesh Kadandale, R. S. Hari, Bidipta Roy, Manjula Das, and Hardik J. Pandya., \"Lab-on-PCB-Based Electrical Immunosensing Platform for Point-of-Care Detection of SARS-CoV-2,\" in IEEE Sensors Letters, vol. 7, no. 1, pp. 1-4, Jan. 2023, Art no. 4500204, doi: 10.1109\/LSENS.2022.3228306.<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-dot-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 8C119.033 8 8 119.033 8 256s111.033 248 248 248 248-111.033 248-248S392.967 8 256 8zm80 248c0 44.112-35.888 80-80 80s-80-35.888-80-80 35.888-80 80-80 80 35.888 80 80z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Chaudhary, N., Choudhary, B.S., Shah, S.G., Khapare, N., Dwivedi, N., Gaikwad, A., Joshi, N., Raichanna, J., Basu, S., Gurjar, M. and PK.Smitha., 2021. Lipocalin 2 expression promotes tumor progression and therapy resistance by inhibiting ferroptosis in colorectal cancer. International Journal of Cancer, 149(7), pp.1495-1511.<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-27c71de elementor-widget elementor-widget-button\" data-id=\"27c71de\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/scholar.google.com\/citations?user=nbKQHZAAAAAJ&#038;hl=en%20\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">View More Complete list of Publications<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Dr. Smitha P.K., Ph.D. Product Research Group and Gynecologic Oncology division Dr. Smitha P.K., Ph.D. leads the Product Research Group and Gynecologic Oncology division, bringing over 18+ years of experience in molecular diagnostics, immune theragnostics, and translational research. She received her doctoral training in molecular biology and immunology from Bharathiar University and has over 12+ years of biotechnology industry experience spanning research, product development, and clinical translation. She is an expert in the development and characterization of monoclonal hybridomas, recombinant antibodies, and therapeutic proteins, and has led the development of several diagnostic platforms. Her contributions are reflected in peer-reviewed publications, filed patents, and ongoing translational innovations.\u00a0 Her current research integrates product development with gynecologic oncology, with a major focus on ovarian cancer, where she is developing patient-derived 3D organoid platforms for functional drug testing. These models enable cell-based assays to evaluate chemotherapy response, support personalized treatment strategies, and critically, investigate the molecular and functional mechanisms underlying drug resistance. In addition to functional screening, her work focuses on understanding how tumor heterogeneity, microenvironmental factors, and intercellular communication contribute to the emergence and propagation of chemoresistance, enabling the development of more effective therapeutic strategies. In parallel, she is actively working on the early detection of cervical cancer, developing novel diagnostic approaches aimed at improving screening, early intervention, and patient outcomes. &gt; What patients are saying Rating * 5 star(s) 4 star(s) 3 star(s) 2 star(s) 1 star(s) Title Review * Submit Review Address Address: Billrothstrasse 78, 1190 Vienna, Austria Email: limpid@info.com Phone: +1(213)555-3890 Working Hours Monday 8AM-7PM Tuesday 8AM-7PM Wednesday 8AM-7PM Thursday 8AM-7PM Saturday 8AM-7PM Publications Dwivedi N, Mazumder T, Tihara S, Veeraraghavan G, Siva R, Smitha PK, Ranade R, KM A, Dhar SK, Das M. In vitro and In Vivo Evidences Propound Potential of Lipocalin 2 as a Therapeutic Target in Cervical Carcinoma. Journal of Cancer Science and Clinical Therapeutics. 2023;7:233-48. Nehanjali Dwivedi, Hafsa Bahaar, DN Shashank, Christine Elizabeth Cherry, Charitha Gangadharan, Amritha Suresh, Moni A Kuriakose, Vijay Pillai, Smitha PK, and Manjula Das. Novel cancer associated fibroblasts from diverse locales enhance the tumorigenicity of tongue Tumor Epithelia. Dental Research and Oral Health. 6 (2023): 65-78. Choudhary BS, Chaudhary N, Shah M, Dwivedi N, P K Smitha, Das M, Dalal SN. Lipocalin 2 inhibits actin glutathionylation to promote invasion and migration. FEBS Lett. 2023 Jan 17. doi: 10.1002\/1873-3468.14572. Epub ahead of print. PMID: 36650979. Joshi, Anju, Anil Vishnu GK, Smitha P.K, Ashlesh Kadandale, R. S. Hari, Bidipta Roy, Manjula Das, and Hardik J. Pandya., &#8220;Lab-on-PCB-Based Electrical Immunosensing Platform for Point-of-Care Detection of SARS-CoV-2,&#8221; in IEEE Sensors Letters, vol. 7, no. 1, pp. 1-4, Jan. 2023, Art no. 4500204, doi: 10.1109\/LSENS.2022.3228306. Chaudhary, N., Choudhary, B.S., Shah, S.G., Khapare, N., Dwivedi, N., Gaikwad, A., Joshi, N., Raichanna, J., Basu, S., Gurjar, M. and PK.Smitha., 2021. Lipocalin 2 expression promotes tumor progression and therapy resistance by inhibiting ferroptosis in colorectal cancer. International Journal of Cancer, 149(7), pp.1495-1511. View More Complete list of Publications<\/p>\n","protected":false},"featured_media":3913,"template":"","class_list":["post-4016","doctor","type-doctor","status-publish","has-post-thumbnail","hentry","doctor_cat-executive-management"],"acf":[],"_links":{"self":[{"href":"https:\/\/arranstudio.com\/msctr\/wp-json\/wp\/v2\/doctor\/4016","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/arranstudio.com\/msctr\/wp-json\/wp\/v2\/doctor"}],"about":[{"href":"https:\/\/arranstudio.com\/msctr\/wp-json\/wp\/v2\/types\/doctor"}],"version-history":[{"count":9,"href":"https:\/\/arranstudio.com\/msctr\/wp-json\/wp\/v2\/doctor\/4016\/revisions"}],"predecessor-version":[{"id":4964,"href":"https:\/\/arranstudio.com\/msctr\/wp-json\/wp\/v2\/doctor\/4016\/revisions\/4964"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/arranstudio.com\/msctr\/wp-json\/wp\/v2\/media\/3913"}],"wp:attachment":[{"href":"https:\/\/arranstudio.com\/msctr\/wp-json\/wp\/v2\/media?parent=4016"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}